Open Access Research article

Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure

Jacob J Michaelson1, Saskia Trump2, Susanne Rudzok2, Carolin Gräbsch2, Danielle J Madureira3, Franziska Dautel4, Juliane Mai5, Sabine Attinger5, Kristin Schirmer36, Martin von Bergen47, Irina Lehmann2* and Andreas Beyer1*

Author Affiliations

1 Cellular Networks and Systems Biology, Biotechnology Center, TU Dresden, Dresden, Germany

2 Dept. of Environmental Immunology, UFZ, Helmholtz Center for Environmental Research, Leipzig, Germany

3 EAWAG Aquatic Research, ETH Swiss Federal Institute of Technology, Zürich, Switzerland

4 Dept. of Proteomics, UFZ, Helmholtz Center for Environmental Research, Leipzig, Germany

5 Dept. of Computational Hydro Systems, UFZ, Helmholtz Center for Environmental Research, Leipzig, Germany

6 EPF Lausanne, Lausanne, Switzerland

7 Dept. of Metabolomics, UFZ, Helmholtz Center for Environmental Research, Leipzig, Germany

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BMC Genomics 2011, 12:502  doi:10.1186/1471-2164-12-502

Published: 13 October 2011

Additional files

Additional file 1:

supplementary information. A PDF containing additional details on the experiments and analysis.

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Additional file 2:

cluster assignment and regulatory predictions for differentially expressed genes. An XLS file containing the results of our RF classifier.

Format: XLS Size: 334KB Download file

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