Open Access Research article

Analysis of human meiotic recombination events with a parent-sibling tracing approach

Yun-Shien Lee12, Angel Chao3, Chun-Houh Chen4, Tina Chou4, Shih-Yee Mimi Wang5 and Tzu-Hao Wang23*

Author Affiliations

1 Department of Biotechnology, Ming Chuan University, Tao-Yuan, Taiwan

2 Genomic Medicine Research Core Laboratory (GMRCL), Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

3 Department of Obstetrics and Gynecology, Lin-Kou Medical Center, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan

4 Institute of Statistical Science, Academia Sinica, Taipei, Taiwan

5 Department of Obstetrics and Gynecology, White Memorial Medical Center, Los Angeles, CA, USA

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BMC Genomics 2011, 12:434  doi:10.1186/1471-2164-12-434

Published: 26 August 2011

Additional files

Additional file 1:

Calling schema. Tables with calling schema for analyzing meiosis, identity by descent (IBD) and parent-sibling tracing (PST).

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Additional file 2:

Paternal recombination site along the chromosomes. The paternal recombination site of child 1 and 2 of GMRCL dataset (CH1 and CH2, defined in Figure 1) along chromosomes are demonstrated in figures by the identity by descent (IBD) and parent-sibling tracing (PST) methods.

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Additional file 3:

Distribution of recombination events. Figures illustrating the distribution of the 2,145 paternal and 2,145 maternal recombination events in human for each chromosome.

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Additional file 4:

Correlation between tandem repeats sequences and paternal recombination sites. Distribution of the length of the tandem repeats sequences and scatter plot of the number of paternal recombination sites with the tandem repeats sequences.

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Additional file 5:

Detailed information of GSE6754 dataset. Family ID, individual ID and the pedigree relative of the analyzed 3864 samples which were downloaded from GEO, GSE 6754.

Format: XLS Size: 383KB Download file

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