Mapping TCDD-induced AhR enriched regions (FDR < 0.01) and DRE analysis to genes. The 10,283 and 660 AhR enrichments within the intragenic DNA regions at 2 and 24 hrs (blue shaded areas in Figures 5A-B) mapped to 5,307 (A) and 591 (B) distinct genes based on the refGene data from the UCSC Genome Browser. These genes were searched for the presence of high (matrix similarity score (MS) ≥ 0.8473; dark grey areas) and low (MS score < 0.84731; light grey areas) scoring DRE sequences, and the absence of a DRE core (white areas) within the region of AhR enrichment. Comparing 2 and 24 hrs data identified 575 overlapping genes with AhR enrichment and 513 of these genes contained a DRE core within the region of enrichment (C).
Dere et al. BMC Genomics 2011 12:365 doi:10.1186/1471-2164-12-365