Open Access Highly Accessed Methodology article

The differential disease regulome

Geir K Sandve1, Sveinung Gundersen2, Halfdan Rydbeck134, Ingrid K Glad5, Lars Holden3, Marit Holden3, Knut Liestøl14, Trevor Clancy2, Finn Drabløs6, Egil Ferkingstad3, Morten Johansen7, Vegard Nygaard7, Eivind Tøstesen7, Arnoldo Frigessi38 and Eivind Hovig1237*

Author Affiliations

1 Department of Informatics, University of Oslo, Blindern, 0316 Oslo, Norway

2 Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway

3 Statistics For Innovation, Norwegian Computing Center, 0314 Oslo, Norway

4 Centre for Cancer Biomedicine, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway

5 Department of Mathematics, University of Oslo, Blindern, 0316 Oslo, Norway

6 Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway

7 Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway

8 Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Blindern, 0317 Oslo, Norway

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BMC Genomics 2011, 12:353  doi:10.1186/1471-2164-12-353

Published: 7 July 2011

Additional files

Additional file 1:

Supplemental material for "The differential disease regulome". Miscellaneous supplemental material: details on the Genomic HyperBrowser; overview of generated regulomes; details on immunology example; additional example from a disease regulome variant; statistics overview and supplemental figures.

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Additional file 2:

TF-disease clusters. A listing of 57 manually indentified TF-disease clusters in the differential disease regulome.

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Additional file 3:

TF-GO clusters. A listing of 105 manually indentified TF-GO clusters in the Gene Ontology regulome.

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Additional file 4:

Gene listings for immunology example. Listings of all the genes of the immunology clusters in the differential disease regulome and the Gene Ontology regulome, sorted on their hit rate. The genes indicated in the different sections of the Venn diagram in Figure 4 are also detailed here.

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