Open Access Highly Accessed Research article

Immunogenicity of autoantigens

Christina Backes1*, Nicole Ludwig2, Petra Leidinger2, Christian Harz2, Jana Hoffmann2, Andreas Keller2, Eckart Meese2 and Hans-Peter Lenhof1

Author Affiliations

1 Center for Bioinformatics, Saarland University, 66041 Saarbrücken, Germany

2 Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany

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BMC Genomics 2011, 12:340  doi:10.1186/1471-2164-12-340

Published: 4 July 2011

Additional files

Additional file 1:

Figure S1: Overview of all significant GO categories. Heat maps showing the significantly enriched GO terms in the considered data sets compared to the ProteinCodingGenes reference set (left-hand side) or compared to the ProteinCodingGenesLongerExons reference set (right-hand side). ALL: union of all antigen sets; CIDB-Serex-AG: retrieved from the Cancer Immunome Database (SEREX method); Exp-Chip-AG: mixed antigens (tumor/non-tumor diseases) identified by protein macroarray; Exp-Serex-HAG: natural occurring autoantigens (SEREX method); Exp-Serex-TAG: tumor antigens (SEREX method); Lit-AAG: autoimmune antigens collected by literature search; Lit-PhageDisplay-TAG: tumor antigens identified by Phage Display experiments collected by literature search.

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Additional file 2:

Figure S2: Overview of all significant KEGG categories. Heat maps showing the significantly enriched KEGG pathways in the considered data sets compared to the ProteinCodingGenes reference set (left-hand side) or compared to the ProteinCodingGenesLongerExons reference set (right-hand side). ALL: union of all antigen sets; CIDB-Serex-AG: retrieved from the Cancer Immunome Database (SEREX method); Exp-Chip-AG: mixed antigens (tumor/non-tumor diseases) identified by protein macroarray; Exp-Serex-HAG: natural occurring autoantigens (SEREX method); Exp-Serex-TAG: tumor antigens (SEREX method); Lit-AAG: autoimmune antigens collected by literature search; Lit-PhageDisplay-TAG: tumor antigens identified by Phage Display experiments collected by literature search.

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