Table 3 |
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Dog genes and human orthologs within the selective sweep on CFA 26. |
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|
Boxer |
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|
|
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|
Human gene |
Dog gene |
Start (bp) |
End (bp) |
Ensembl Gene ID |
Annotation |
|
|
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|
HIP1R |
HIP1R |
9,641,249 |
9,654,192 |
ENSCAFG00000007764 |
Development of vertebral column |
|
P2RX4 |
Q64F94_CANFA |
10,917,230 |
10,933,173 |
ENSCAFG00000008363 |
Contraction (and relaxation) of cardiac muscle |
|
P2RX7 |
B0FLR1_CANFA |
10,959,759 |
11,002,514 |
ENSCAFG00000008401 |
Bone mineral density of skeleton Formation of perichondral bone Resorption of trabecular bone |
|
ATP2A2 |
AT2A2_CANFA |
11,167,290 |
11,232,956 |
ENSCAFG00000008434 |
Contraction (and relaxation) of cardiac muscle Contraction and relaxation of papillary muscle Elongation of cardiomyocytes |
|
POLE |
POLE |
3,436,073 |
3,481,729 |
ENSCAFG00000006215 |
Lymphoblastic lymphoma |
|
MYL2 |
NP_001003069.1 |
11,482,695 |
11,650,673 |
ENSCAFG00000008524 |
Contraction of cardiac muscle Development of sarcomere Cardiomyopathy of heart ventricle |
|
|
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|
Boxer, English and French bulldogs |
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|
|
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|
Human gene |
Dog gene |
Start (bp) |
End (bp) |
Ensembl Gene ID |
Annotation |
|
|
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|
CCDC92 |
CCDC92 |
8,759,998 |
8,790,267 |
ENSCAFG00000006996 |
Amino Acid Metabolism Protein Synthesis Small Molecule Biochemistry |
|
ATP6V0A2 |
ATP6V0A2 |
8,929,687 |
8,968,952 |
ENSCAFG00000007234 |
Cutis laxa Wrinkly skin syndrome |
|
EIF2B1 |
EIF2B1 |
9,029,462 |
9,038,275 |
ENSCAFG00000007434 |
Gene Expression Leukoencephalopathy with vanishing white matter Protein Synthesis |
|
DDX55 |
DDX55 |
9,040,108 |
9,053,306 |
ENSCAFG00000007452 |
Cancer Infection Mechanism (by HIV) |
|
TMED2 |
TMED2 |
9,056,220 |
9,064,265 |
ENSCAFG00000007468 |
Cancer Infection Mechanism (by HIV) |
|
SETD8 |
9,188,951 |
9,202,238 |
ENSCAFG00000007493 |
Tissue development and cell cycle |
|
|
|
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|
The upper part of the table (Boxer) refers to the selective sweep present in the Boxer only (CFA 26:3,008,718-11,914,284 bp). The lower part of the table (Boxer, English and French bulldogs) refers to the part of the selective sweep shared in the three breeds CFA 26:8,548,679-9,227,043 bp. Genomic positions in the dog genome and their annotated involvement in biological process and diseases (italic bold) are listed. |
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|
Quilez et al. BMC Genomics 2011 12:339 doi:10.1186/1471-2164-12-339 |
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