Table 3

Dog genes and human orthologs within the selective sweep on CFA 26.

Boxer


Human gene

Dog gene

Start (bp)

End (bp)

Ensembl Gene ID

Annotation


HIP1R

HIP1R

9,641,249

9,654,192

ENSCAFG00000007764

Development of vertebral column

P2RX4

Q64F94_CANFA

10,917,230

10,933,173

ENSCAFG00000008363

Contraction (and relaxation) of cardiac muscle

P2RX7

B0FLR1_CANFA

10,959,759

11,002,514

ENSCAFG00000008401

Bone mineral density of skeleton

Formation of perichondral bone

Resorption of trabecular bone

ATP2A2

AT2A2_CANFA

11,167,290

11,232,956

ENSCAFG00000008434

Contraction (and relaxation) of cardiac muscle

Contraction and relaxation of papillary muscle

Elongation of cardiomyocytes

POLE

POLE

3,436,073

3,481,729

ENSCAFG00000006215

Lymphoblastic lymphoma

MYL2

NP_001003069.1

11,482,695

11,650,673

ENSCAFG00000008524

Contraction of cardiac muscle

Development of sarcomere

Cardiomyopathy of heart ventricle


Boxer, English and French bulldogs


Human gene

Dog gene

Start (bp)

End (bp)

Ensembl Gene ID

Annotation


CCDC92

CCDC92

8,759,998

8,790,267

ENSCAFG00000006996

Amino Acid Metabolism

Protein Synthesis

Small Molecule Biochemistry

ATP6V0A2

ATP6V0A2

8,929,687

8,968,952

ENSCAFG00000007234

Cutis laxa

Wrinkly skin syndrome

EIF2B1

EIF2B1

9,029,462

9,038,275

ENSCAFG00000007434

Gene Expression

Leukoencephalopathy with vanishing white matter

Protein Synthesis

DDX55

DDX55

9,040,108

9,053,306

ENSCAFG00000007452

Cancer

Infection Mechanism (by HIV)

TMED2

TMED2

9,056,220

9,064,265

ENSCAFG00000007468

Cancer

Infection Mechanism (by HIV)

SETD8

9,188,951

9,202,238

ENSCAFG00000007493

Tissue development and cell cycle


The upper part of the table (Boxer) refers to the selective sweep present in the Boxer only (CFA 26:3,008,718-11,914,284 bp). The lower part of the table (Boxer, English and French bulldogs) refers to the part of the selective sweep shared in the three breeds CFA 26:8,548,679-9,227,043 bp. Genomic positions in the dog genome and their annotated involvement in biological process and diseases (italic bold) are listed.

Quilez et al. BMC Genomics 2011 12:339   doi:10.1186/1471-2164-12-339

Open Data