Nucleosome is enriched within pre-miRNA genomic sequence. The y axis represents the value of nucleosome occupancy. Position zero on X axis corresponds to the center of pre-miRNA genomic sequence. (A) Nucleosome occupancy profiles within 2,000-nt windows surrounding the centers of intronic, intergenic and exonic pre-miRNAs in resting CD4+ T cells. (B) The nucleosome occupancy profiles along the pre-miRNA genomic sequences in C. elegans. (C) Nucleosome occupancy profiles within 2,000-nt windows surrounding the centers of pre-miRNA genomic sequences corresponding to active-promoter miRNA, inactive-promoter miRNA, expressed miRNA and unexpressed miRNA. (D) Distribution of nucleosome occupancy in five groups of miRNAs with different expression levels. Five groups are defined according to the corresponding mature miRNA expression levels. Five different colors indicate the different levels of nucleosome occupancy in a 400-nt window surrounding the center of pre-miRNA.
Zhu et al. BMC Genomics 2011 12:329 doi:10.1186/1471-2164-12-329