Table 2

Functional analysis of differentially expressed EGF responsive genes.

TOP NETWORKS

Associated Network Functions

Focus Molecules

Score


1. Cell Death, Embryonic Development, Renal and Urological Disease

28

45

2. Amino Acid Metabolism, Post-Translational Modification, Small Molecule Biochemistry

26

40

3. Cell Cycle, Cancer, Cardiovascular System Development and Function

24

35

4. Cellular Growth and Proliferation, Hematological System and Connective Tissue Development and Function

24

35

5. Cellular Movement, Cellular Assembly and Organization, Cell-to-Cell Signaling and Interaction

24

35


TOP BIOLOGICAL FUNCTIONS

Molecular and Cellular Functions

p-value

Molecules


1. Cell Death

7.41e-19-6.45e-04

145

2. Cell Growth and Proliferation

1.77e-16-6.15e-04

160

3. Cellular Movement

3.16e-12-6.50e-04

101

4. Cellular Development

9.85e-11-6.28e-04

115

5. Cell Cycle

1.23e-10-6.63e-04

75


Diseases and Disorders

p-value

Molecules


1. Cancer

1.82e-17-6.63e-04

193

2. Reproductive System Disease

5.14e-15-6.57e-04

98

3. Immunological Disease

1.09e-10-6.63e-04

70

4. Dermatological Disease and Conditions

1.59e-08-3.33e-04

61

5. Inflammatory Disease

1.59e-08-5.61e-04

58


List of Ingenuity Networks and Biological Functions generated by mapping the 1164 focus molecules that were differentially expressed during EGF treatment according to RankProd.

Llorens et al. BMC Genomics 2011 12:326   doi:10.1186/1471-2164-12-326

Open Data