Additional file 10.

Figure S1. Histopathology images of zebrafish HCC and healthy zebrafish liver. A. Zebrafish liver section with hepatocellular carcinoma (HCC) invasion into surrounding normal liver tissue. HCC and surrounding normal tissue are labeled. B. Enlarged image of the section indicated with a box in image A showing the boundary between HCC and normal tissue. C. Normal control liver section. Normal zebrafish hepatocytes are typically organized in two-cell thick plates and are regular throughout the whole liver. Carcinomas lose this plate architecture completely and are reorganized in typical patterns, such as a trabecular pattern with several-cell thick irregular trabeculae, a glandular pattern with a central clear space surrounded by one-cell layer neoplastic hepatocytes, and a large sheet of neoplastic cells without any recognizable pattern. Carcinoma cells are cuboidal with centrally localized nuclei of variable sizes.

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Mirbahai et al. BMC Genomics 2011 12:3   doi:10.1186/1471-2164-12-3