Table 1

Genes under diversifying selection identified by both models

ORF Number

Gene Family Name

Category

VACV-Cop ORF

Specific Function

Virion


021

EGF_Growth factor

Host Response Modifier

C11R

EGF homolog with mitogenic activity

No


024

IL_18_BP (Bsh_D7L)

Host Response Modifier

n/a

Inhibition of IL-18 activity

No


035

Kelch_like_ (Cop_C2L)

Host Response Modifier

C2L

Unknown

No


036

Unknown (Cop_C1L)

Unknown

C1L

Unknown

No


046

Unknown (Cop_K7R)

Entry/Exit

K7R

inhibitor of pattern recognition receptor signalling pathway

No


048

Apoptosis inhibitor (mitochondrial associated)

Host Response Modifier

F1L

localizes to mitochondria and inhibits apoptosis

No


054

Unknown (Cop_F6L)

Unknown

F6L

Unknown

No


055

Unknown (Cop_F7L)

Unknown

F7L

Unknown

No


056

Cytoplasmic protein (Cop_F8L)

Unknown

F8L

Cytoplasmic localization, unknown function

No


063

Unknown (Cop_F14L)

Unknown

F14L

Unknown

No


129

Carbonic anhydrase Virion

Entry/Exit

D8L

Binds Chondroitin Sulfate on cell surface

Yes


140

Core_protein (Cop_A4L)

Structure/Assembly

A4L

associated with virion core and membranes

Yes


145

Membrane protein (Cop_A9L)

Structure/Assembly

A9L

located on virion membrane, essential for morphogenesis

Yes


162

RNA pol 132 (RPO132)

RNA metabolism

A24R

Component of RNA polymerase

Yes


171

Unknown (YMTV_120.5L)

Unknown

A30.5L

Unknown

No


172

Unknown (Cop_A31R)

Host Response Modifier

A31R

Unknown

Yes


182

Semaphorin

Host Response Modifier

A39R

Induces IL-6 and IL-8 secretion from monocytes

No


191

Unknown (Cop_A47L)

Unknown

A47L

Unknown

No


192

Thymidylate kinase

DNA metabolism

A48R

Thymidylate kinase activity

No


200

Hemagglutinin

Host Response Modifier

A56R

prevents cell-cell fusion, present on EEV and cell surface

Yes


203

Schlafen (Cop_B2R)

Host Response Modifier

B2R

Virulence factor in CMLV

No


204

Ankyrin (Cop_B4R)

Unknown

B4R

Unknown

No


212

Ser_Thr_Kinase (Cop_B12R)

Unknown

B12R

Unknown

No


215

IL_1_beta receptor

Host Response Modifier

B15R

Inhibits IL-1 beta activity

No


216

Unknown (Cop_B17L)

Unknown

B17R

Unknown

No


Esteban and Hutchinson BMC Genomics 2011 12:261   doi:10.1186/1471-2164-12-261

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