Table 4

Biological Processes enriched in Se-specific genes

GO Identifier

Term

Total Genes1

Changed Genes2

Enrich ment

FDRc


Cell movement/morphogenesis

GO:0006929

substrate-bound_cell_migration

11

4

9.37

0.032

GO:0007155

cell_adhesion

586

47

2.07

0.000

GO:0022610

biological_adhesion

586

47

2.07

0.000

GO:0008360

regulation_of_cell_shape

49

11

5.78

0.000

GO:0022604

regulation_of_cell_morphogenesis

126

18

3.68

0.000

GO:0000902

cell_morphogenesis

386

29

1.94

0.021

GO:0032989

cellular_component_morphogenesis

423

34

2.07

0.000

GO:0051128

regulation_of_cellular_component_organization

429

32

1.92

0.014

Extra cellular matrix

GO:0030199

collagen_fibril_organization

23

6

6.72

0.006

GO:0030198

extracellular_matrix_organization

88

14

4.10

0.000

GO:0030036

actin_cytoskeleton_organization

248

25

2.60

0.000

GO:0043062

extracellular_structure_organization

156

15

2.48

0.045

GO:0030029

actin_filament-based_process

263

25

2.45

0.000

GO:0007010

cytoskeleton_organization

417

33

2.04

0.001

Development/Angiogenesis

GO:0010926

anatomical_structure_formation

980

59

1.55

0.018

GO:0048856

anatomical_structure_development

2224

132

1.53

0.000

GO:0009653

anatomical_structure_morphogenesis

1158

78

1.74

0.000

GO:0022603

regulation_of_anatomical_structure_morphogenesis

260

27

2.68

0.000

GO:0048646

anatomical_structure_formation_involved_in_morphogenesis

346

30

2.23

0.000

GO:0001570

Vasculogenesis

40

8

5.15

0.004

GO:0001525

Angiogenesis

182

19

2.69

0.002

GO:0001568

blood_vessel_development

278

27

2.50

0.000

GO:0048514

blood_vessel_morphogenesis

237

23

2.50

0.000

GO:0001944

vasculature_development

282

27

2.47

0.000

GO:0009887

organ_morphogenesis

735

47

1.65

0.021

GO:0048731

system_development

2107

119

1.46

0.000

GO:0048869

cellular_developmental_process

1545

87

1.45

0.003

GO:0048513

organ_development

1633

91

1.44

0.004

GO:0007275

multicellular_organismal_development

2439

130

1.37

0.000

GO:0032502

developmental_process

2955

148

1.29

0.003

Other

GO:0034329

cell_junction_assembly

41

7

4.40

0.043

GO:0007165

signal_transduction

2543

127

1.29

0.020

GO:0032501

multicellular_organismal_process

3222

154

1.23

0.039


Gene ontology (GO) identifiers significantly enriched in the 667 Se-specific genes. 1Number of genes involved in this process in the set of all genes on the Rat Genome 230 2.0 Array, 2Number of genes involved in this process in the set of genes specific to Se toxicity, 3False Discovery Rate - ratio of the number of times the Se toxicity data gave P < 0.05 compared to a random set of data

Raines and Sunde BMC Genomics 2011 12:26   doi:10.1186/1471-2164-12-26

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