Table 1

Transcripts up-regulated by Se deficiency

Genbank Accession

Gene Symbol

Gene Title

Fold Change1

adj P-value2

Nrf2 Target3


Mouse Liver

NM_173047

Cbr3

carbonyl reductase 3

7.46

1.7E-05

X

NM_001033336

Abcc4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

3.73

0.023

X

NM_013560

Hspb1

heat shock protein 1

1.91

0.04

- - - - - - - - - - - - - - - - - - - - - - - - -

NM_008182

Gsta2

glutathione S-transferase, alpha 2

1.93

0.057

NM_007620

Cbr1

carbonyl reductase 1

1.89

0.057

X

NM_008706

Nqo1

NADPH dehydrogenase, quinone 1

1.85

0.073

X

NM_010357

Gsta4

glutathione S-transferase, alpha 4

1.74

0.17

X

Mouse Kidney

- - - - - - - - - - - - - - - - - - - - - - - - -

NM_001077353

Gsta3

glutathione S-transferase, alpha 3

1.74

0.076

X

NM_001033336

Abcc4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

1.89

0.11

X

NM_008706

Nqo1

NADPH dehydrogenase, quinone 1

1.64

0.29

X

Rat Liver4

NM_173323

Ugt2b7

UDP glucuronosyltransferase 2 family, polypeptide B7

2.14

0.01

NM_001009920

Gsta5

glutathione S-transferase Yc2 subunit

3.03

0.02

- - - - - - - - - - - - - - - - - - - - - - - - -

NM_080581

Abcc3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

4.29

0.07

X

NM_033443

Arsb

arylsulfatase B

1.40

0.07

NM_017000

Nqo1

NADPH dehydrogenase, quinone 1

1.99

0.16

X


Transcripts that were significantly (above dashed line, P < 0.05) or nearly significantly (below dashed line, 0.05 < P < 0.2) up-regulated in Se-deficient rodent tissues compared to Se-adequate (0.2 or 0.24 μg Se/g diet, for mouse and rat studies respectively). 1Fold changes determined by analysis of RMA expression data with the Limma package in R software, 2P-values were adjusted for multiple testing, 3Genes known to be Nrf2 targets, determined as described in the text, 4 Genes up-regulated in Se-deficient liver from rats in study 2.

Raines and Sunde BMC Genomics 2011 12:26   doi:10.1186/1471-2164-12-26

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