Additional file 3.

MetaCyc data Pichia pastoris. Regulated P. pastoris pathways in hypoxia vs. normoxia. Individual P. pastoris (recombinant strain) pathways that were transcriptionally regulated (i e. exceeding the log2 FC threshold of 0.59) in the comparison hypoxic vs. normoxic conditions, as resulting from the MetaCyc analysis presented in Figure 3 webcite. Pathway numbers in the first column are referred to Figure 3. Pathway diagrams show all the intermediates of each pathways; reaction lines and the corresponding genes are colour-coded (three colour bins) according to the fold change threshold: red for upregulated, yellow for downregulated and blue for unregulated; log2 FC for each gene are also shown in colour. Last column contains the extended enzyme names corresponding to each gene of the pathway.

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Baumann et al. BMC Genomics 2011 12:218   doi:10.1186/1471-2164-12-218