Table 8

Top regulated adipocyte genes in bone marrow adipocytes with age

Symbol

Entrez Gene Name

14M

18M

p-value (cell type*age)


TNFα

tumor necrosis factor α

2.37

-1.38

1.47E-05

FOXO1

forkhead box O1

1.99

1.17

0.0006

IRS2

insulin receptor substrate 2

1.93

-1.08

0.0008

C/EBPβ

CCAAT/enhancer binding protein beta

1.79

-1.23

1.22E-05

CD36

fatty acid translocase

1.38

2.00

0.001

PPARγ

peroxisome proliferator-activated receptor gamma

1.36

1.08

0.003

PLIN3

perilipin 3, TIP47

1.25

1.04

0.007

SOD2

superoxide dismutase 2, mitochondrial

1.24

-1.09

0.001

UCP2

uncoupling protein 2

1.24

1.18

8.1E-06

LIPE

lipase, hormone sensitive

1.23

-1.27

2.1E-05

SERPINE1

plasminogen activator inhibitor type 1

1.21

-1.30

0.0004

GPX1

glutathione peroxidase 1

1.04

1.23

0.0002

SLC2A4

GLUT-4

-1.11

1.30

0.04

CFD

adipsin

-1.12

1.25

0.002

FABP4

fatty acid binding protein 4, adipocyte

-1.52

-2.46

0.001

PTPN11

protein tyrosine11

-1.58

-1.21

0.0006

ADIPOR2

adiponectin receptor 2

-1.66

-1.44

0.001

LEPR

leptin receptor

-1.94

1.44

0.002

IL6

interleukin 6 (interferon, beta 2)

-2.19

-1.91

8.34E-05

ADIPOQ

adiponectin

-2.25

-1.88

0.01


The list includes the adipocyte genes that change with age in bone marrow adipocytes. The set of regulated genes was selected on the basis of their expression in adipose according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in bone marrow adipocytes from mice. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA.

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

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