Table 7

Age-related fold changes in genes involved in mitochondrial function

Bone marrow

Epididymal

Symbol

Entrez Gene Name

14M

18M

14M

18M


CASP9

caspase 9, apoptosis-related cysteine peptidase

1.51

1.38

1.27

1.23

GLRX2

glutaredoxin 2

1.36

1.79

-1.05

1.38

GPX4

glutathione peroxidase 4 (phospholipid hydroperoxidase)

1.08

1.30

-1.12

-1.11

MAOB

monoamine oxidase B

-1.23

-1.39

-1.06

1.31

MT-ND4L

NADH dehydrogenase, subunit 4L (complex I)

-1.25

-1.63

-1.22

-1.17

NDUFA4

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa

1.11

1.81

-1.21

1.00

NDUFA7

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5 kDa

-1.72

-1.69

-1.15

1.12

NDUFA11

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7 kDa

-1.46

-1.68

-1.07

1.04

NDUFA12

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12

-1.58

-1.71

-1.11

1.09

NDUFA13

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

-1.05

-1.33

-1.26

-1.30

NDUFA4L2

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2

-1.26

-1.38

1.50

1.05

NDUFA9 (includes EG:4704)

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa

1.11

1.77

-1.46

1.10

NDUFAF1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1

1.18

1.87

-1.41

1.42

NDUFB8

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19 kDa

-1.31

-1.40

-1.35

1.09

NDUFB10

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22 kDa

-1.46

-1.38

-1.18

1.01

NDUFB11

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3 kDa

-1.58

-1.38

-1.18

-1.13

NDUFS1

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75 kDa (NADH-coenzyme Q reductase)

1.29

2.22

-1.21

1.67

NDUFS4

NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18 kDa (NADH-coenzyme Q reductase)

-1.22

-1.39

-1.03

1.48

NDUFS7

NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20 kDa (NADH-coenzyme Q reductase)

-1.53

-1.51

-1.16

-1.08

NDUFS8

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)

-1.37

-1.52

1.14

1.46

NDUFS6 (includes EG:4726)

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13 kDa (NADH-coenzyme Q reductase)

1.01

1.68

-1.08

1.29

NDUFV2

NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa

-1.54

-1.31

-1.27

1.26

NDUFV3

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10 kDa

-1.24

-1.38

-1.11

-1.12

PDHA1 (includes EG:5160)

pyruvate dehydrogenase (lipoamide) alpha 1

1.62

1.85

-1.20

1.45

PRDX3

peroxiredoxin 3

1.19

2.39

-1.42

1.19

SDHA

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

1.31

1.51

-1.35

1.06

SDHB

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

-1.25

-1.31

-1.35

1.10

SNCA

synuclein, alpha (non A4 component of amyloid precursor)

-1.08

1.67

-1.16

-3.22

UQCRFS1

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

1.20

1.49

-1.68

-1.05

UQCRH

ubiquinol-cytochrome c reductase hinge protein

-1.14

-1.32

-1.27

1.24


The list includes the mitochondrial genes that change with age in bone marrow and epididymal adipocytes. The set of regulated genes was selected on the basis of their expression in adipose cells according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in bone marrow adipocytes. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA.

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

Open Data