Table 5

Age-associated fold changes in genes involved in adipocyte differentiation

Bone marrow

Epididymal

Symbol

Entrez Gene Name

14M

18M

14M

18M


AR

androgen receptor

-1.84

-2.03

-1.47

-1.82

ARL4A

ADP-ribosylation factor-like 4A

-1.34

1.28

-2.04

1.03

CCND1

cyclin D1

1.26

1.11

2.48

-1.64

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

-1.51

-1.43

-1.33

1.15

DDIT3

DNA-damage-inducible transcript 3

1.22

-2.14

-1.76

-1.16

EBF1

early B-cell factor 1

1.43

-1.50

-1.28

-1.41

EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

1.80

1.17

1.70

1.53

FABP4

fatty acid binding protein 4, adipocyte

-1.54

-2.57

-1.23

-1.32

FGF10

fibroblast growth factor 10

1.23

1.18

-2.60

1.04

FN1

fibronectin 1

1.36

-1.18

7.06

-3.16

IL6

interleukin 6 (interferon, beta 2)

-2.04

-2.07

-20.53

-5.56

IL1B

interleukin 1, beta

1.37

-1.48

-2.26

-2.16

INSIG1

insulin induced gene 1

1.26

1.49

1.33

2.81

IRS2

insulin receptor substrate 2

1.96

-1.13

-4.26

-2.94

LAMA4

laminin, alpha 4

-1.44

-1.38

-1.41

-1.18

LEP

leptin

-2.02

-1.77

1.01

1.59

LIF

leukemia inhibitory factor (cholinergic differentiation factor)

1.88

1.11

-1.03

-1.07

NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

1.29

1.02

1.01

1.15

PARP2

poly (ADP-ribose) polymerase 2

1.35

1.24

1.30

1.21

PPARGC1A

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

1.41

-1.09

-1.05

2.02

PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

-1.34

1.03

3.29

-1.59

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

1.43

-2.09

-3.75

-5.58

RARA

retinoic acid receptor, alpha

-1.30

-2.35

1.06

-1.49

RETNLA

resistin like alpha

-1.32

-1.11

2.96

-10.77

SCD

stearoyl-CoA desaturase (delta-9-desaturase)

1.80

1.11

1.01

1.05

TNF

tumor necrosis factor

2.36

-1.48

-2.37

-2.18

TRIB2

tribbles homolog 2

2.98

1.17

1.78

-1.18

VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

-1.39

-1.32

-1.12

-1.21


The list includes age-related fold change in genes involved in adipocytes differentiation in bone marrow and epididymal adipocytes. The set of regulated genes was selected according to the IPA knowledge-base. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA. The significance of differences was estimated by a Benjamini-Hochberg corrected p value (p < 0.01).

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

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