Table 10

Age-regulated adipocyte gene expression

Bone marrow

Epididymal


Symbol

Entrez Gene Name

14M

18M

14M

18M

p-value (Age)


TRIB2

tribbles homolog 2 (Drosophila)

3.0

1.2

1.8

-1.2

1.78E-05

TNFα

tumor necrosis factor α

2.4

-1.5

-2.4

-2.2

0.00013

IRS2

insulin receptor substrate 2

2.0

-1.1

-4.3

-2.9

0.00018

EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

1.8

1.2

1.7

1.5

2.12E-06

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

1.4

-2.1

-3.8

-5.6

4.87E-07

PPARGC1α

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

1.4

-1.1

-1.0

2.0

0.0024

IL1β

interleukin 1, beta

1.4

-1.5

-2.3

-2.2

0.00026

FN1

fibronectin 1

1.4

-1.2

7.1

-3.2

4.20E-07

PARP2

poly (ADP-ribose) polymerase 2

1.4

1.2

1.3

1.2

0.0018

CCND1

cyclin D1

1.3

1.1

2.5

-1.6

0.00062

INSIG1

insulin induced gene 1

1.3

1.5

1.3

2.8

0.0057

FGF10

fibroblast growth factor 10

1.2

1.2

-2.6

1.0

0.0031

DDIT3

DNA-damage-inducible transcript 3

1.2

-2.1

-1.8

-1.2

0.0036

C3

complement component 3

1.0

-1.4

2.1

-1.3

0.00052

PNPLA2

patatin-like phospholipase domain containing 2

-1.0

-1.6

-1.4

-1.2

0.0049

ABHD5

αβ hydrolase domain containing 5

-1.0

-1.4

-2.0

-1.1

0.00059

GPR109A

G protein-coupled receptor 109A

-1.2

-4.5

-10.6

-2.7

2.68E-08

RARα

retinoic acid receptor, alpha

-1.3

-2.4

1.1

-1.5

3.42E-05

RETNLα

resistin like alpha

-1.3

-1.1

3.0

-10.8

8.46E-08

ARL4A

ADP-ribosylation factor-like 4A

-1.3

1.3

-2.0

1.0

3.30E-05

EIF4EBP2

eukaryotic translation initiation factor 4E binding protein 2

-1.4

-1.6

-1.6

-1.2

0.0024

LAMA4

laminin, alpha 4

-1.4

-1.4

-1.4

-1.2

0.0065

C/EBPα

CCAAT/enhancer binding protein, alpha

-1.5

-1.4

-1.3

1.1

0.0062

FABP4

fatty acid binding protein 4, adipocyte

-1.5

-2.6

-1.2

-1.3

0.0026

AR

androgen receptor

-1.8

-2.0

-1.5

-1.8

0.00026

LEP

leptin

-2.0

-1.8

1.0

1.6

0.0017

IL6

interleukin 6

-2.0

-2.1

-20.5

-5.6

8.65E-07


The list includes the genes that change with age in both bone marrow and epididymal adipocytes. The set of the 27 regulated genes was selected on the basis of their fold changes across age in both adipocyte populations sorted using Partek Genome Suit software and IPA. The significance of differences was measured by two-way ANOVA. A low value in p indicates the gene is differentially expressed with respect to age. The comparison included 14-month (14M) and 18-month-old (18M) compared to 6-month-old.

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

Open Data