Table 1

Metabolic parameters in aging mice

Parameter

6-month

14-month


Weight (g)

35.0 ± 1.2

41.8 ± 4.0*

Insulin (ng/mL)

0.57 ± 0.16

2.09 ± 0.44*

Glucose (mg/dL)

118.7 ± 12

192.7 ± 17*

Triglyceride (mg/dL)

240.9 ± 3.43

250.7 ± 6.8

Adipokines

Leptin (ng/mL)

3.52 ± 0.77

20.7 ± 2.38*

Resistin (ng/mL)

1.35 ± 0.17

1.85 ± 0.20

Adiponectin (μg/mL)

2.90 ± 0.20

5.66 ± 0.74*

Bone panel

Osteocalcin (ng/mL)

54.4 ± 4.8

31.8 ± 6.8*

RANKL (ng/mL)

0.21 ± 0.03

0.17 ± 0.22

Osteoprotegerin (ng/mL)

2.28 ± 0.40

1.92 ± 0.17


Data are mean ± SE of 6 to 10 mice per age group. Body weights were determined at time of necropsy. Serum metabolites were measured in the fed state. * P < 0.05 vs. 6-month-old.

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

Open Data