Table 7

Chromosomal Coding Sequence (CDS) annotations associated with Methicillin Resistance

Genome

Sensitivity

FemA

FemB

FemC

FemD

FmtA

FmtB

FmtC

HmrA

HmrB

LytH

MecA

MecI

MecR1

CGSSa00

untested

1

1

1

1

1

3

1

1

1

1

0

0

0

CGSSa01

untested

1

1

1

1

1

2

1

1

1

1

1

0

1

CGSSa03

untested

1

1

1

1

1

1

1

1

1

1

1

1

1

COL

MRSA

1

1

1

1

1

1

1

1

1

1

1

0

1

JH1

VISA

1

1

1

1

1

1

1

1

1

1

1

1

1

JH9

VISA

1

1

1

1

1

1

1

1

1

1

1

1

1

MRSA252

MRSA

1

1

1

1

1

2

1

1

1

1

1

1

1

MSSA476

MSSA

1

1

1

1

1

2

1

1

1

1

0

0

0

Mu3

hetero-VISA

1

1

1

1

1

1

1

1

1

1

1

1

1

Mu50

HA-MRVISA

1

1

1

1

1

1

1

1

1

1

1

1

1

MW2

CA-MRSA

1

1

1

1

1

2

1

1

1

1

1

0

1

N315

MRSA

1

1

1

1

1

1

1

1

1

1

1

1

1

NCTC8325

MRSA

1

1

1

1

1

1

1

1

1

1

0

0

0

Newman

MSSA

1

1

1

1

1

1

1

1

1

1

0

0

0

RF122 (ET3-1)

sensitive

1

1

1

1

1

1

1

1

1

1

0

0

0

USA300 (FPR3757)

CA-MRSA

1

1

1

1

1

2

1

1

1

1

1

0

1

USA300TCH15

CA-MRSA

1

1

1

1

1

2

1

1

1

1

1

0

1

Abbreviations (see also Table 1): FemA, essential for MR (glycine interpeptide bridge formation); FemB, involved in MR (glycine interpeptide bridge formation; FemC, involved in MR (glutamine synthetase repressor); FemD (phosphoglucosamine mutase EC 5.4.2.10) involved in MR; FmtA, involved in MR (affects cell wall cross-linking and amidation); FmtB, (Mrp) involved in MR and cell wall biosynthesis; FmtC, (MrpF) involved in MR (L-lysine modification of phosphatidylglycerol); HmrA, involved in MR (amidohydrolase of M40 family); HmrB, Acyl carrier protein involved in MR; LytH, involved in MR (N-acetylmuramoyl-L-alanine amidase, EC 3.5.1.28 domain); MecA, Penicillin-binding protein PBP2a, MR determinant, transpeptidase; MecI, MR repressor; MecR1, MR regulatory sensor-transducer.

Boissy et al. BMC Genomics 2011 12:187   doi:10.1186/1471-2164-12-187