NFI-C transcription factor acts as more potent activator of gene expression than repressor. A. Differences in the gene expression levels in wild-type (WT) and NFI-C knock-out (KO) mouse embryonic fibroblasts were depicted for 1000 most up-regulated genes and 1000 most down-regulated genes by NFI-C, as well as for 3 independently selected random groups of 1000 genes. On the y-axis: for each gene in such defined groups expression level in knock-out cells was subtracted from the WT expression level (Ewt-Eko) and plotted as an absolute value. B. Affymetrix expression levels in WT cells (Ewt) for 1000 most up-regulated genes by NFI-C, 1000 most down-regulated genes by NFI-C, and 3 sets of 1000 randomly chosen genes.
Pjanic et al. BMC Genomics 2011 12:181 doi:10.1186/1471-2164-12-181