Open Access Research article

In depth analysis of genes and pathways of the mammary gland involved in the pathogenesis of bovine Escherichia coli-mastitis

Bart Buitenhuis1*, Christine M Røntved2, Stefan M Edwards1, Klaus L Ingvartsen2 and Peter Sørensen1

Author Affiliations

1 Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Blichers allé 20, P.O. Box 50, DK-8830 Tjele, Denmark

2 Department of Animal Health and Bioscience, Faculty of Agricultural Sciences, Aarhus University, Blichers allé 20, P.O. Box 50, DK-8830 Tjele, Denmark

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BMC Genomics 2011, 12:130  doi:10.1186/1471-2164-12-130

Published: 28 February 2011

Additional files

Additional file 1:

Table S1: Differentially expressed transcripts for the acute phase response to E. coli infection in the bovine udder.

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Additional file 2:

Table S2: Significant GO identifiers detected based on the differentially expressed transcripts in cluster 1 for the acute phase response to E. coli infection. A hypergeometric gene set enrichment test was performed based on cluster 1 of the contrast T24 vs. C24. Overrepresentation of gene sets defined by the GO database http://www.geneontology.org/ webcite was tested using the Fisher's exact test. A gene set was considered significant if P < 0.05.

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Additional file 3:

Table S3: Significant GO identifiers detected based on the differentially expressed transcripts in cluster 2 for the acute phase response to E. coli infection. A hypergeometric gene set enrichment test was performed based on cluster 2 of the contrast T24 vs. C24. A gene set was considered significant if P < 0.05.

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Additional file 4:

Figure S1: Venn diagram showing the overlap of differentially expressed genes between three studies on E. coli infection in the bovine udder at T = 24 h post-infection. 1) "This study": the study described in this manuscript, 2) "Mitterhuemer": the study described by Mitterhuemer et al. [14], and 3) "Rinaldi": the study described by Rinaldi et al. [15].

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Additional file 5:

Table S4: Overlap of differentially expressed genes between three studies of E. coli infection in the bovine udder. Data from T = 24 h post-infection in three different studies: 1) "This study": the study described in this paper; 2) "Mitterhuemer": the study described by Mitterhuemer et al. [14]; and 3) "Rinaldi": the study described by Rinaldi et al. [15].

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