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Open Access Highly Accessed Research article

Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire

Phuong Nguyen1, Jing Ma2, Deqing Pei3, Caroline Obert4, Cheng Cheng3 and Terrence L Geiger1*

Author Affiliations

1 Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl., Memphis, TN 38105, USA

2 Department of Information Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Pl., Memphis, TN 38105, USA

3 Department of Biostatistics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl., Memphis, TN 38105, USA

4 Hartwell Center for Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Pl., Memphis, TN 38105, USA

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BMC Genomics 2011, 12:106  doi:10.1186/1471-2164-12-106

Published: 11 February 2011

Additional files

Additional file 1:

Supplemental Figure S1. Selective exclusion of erroneous sequences with increasing phred cutoff.

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Additional file 2:

Supplemental Figure S2. Position and nt specific substitutions in phred-filtered data sets.

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Additional file 3:

Supplemental Figure S3. Directional skewing of phred-filtered sequences.

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Open Data