Table 5

List of the human genes in the INHGI with the 10 highest druggability scores

Gene

Druggability score

(Median [min,max])1

N

W

Wc2 (two-tailed p = 0.05)

Druggability evidence3


Normal

Shuffled


HLA-F

0.887[0.803,0.915]

0.530[0.427,0.584]

10

0

8*

No evidence

PLAU4

0.886[0.808,0.907]

0.561[0.387,0.675]

10

0

8*

19301652

CD8A4

0.885[0.871,0.902]

0.56[0.37,0.664]

10

0

8*

No evidence

CD194

0.880[0.751,0.907]

0.562[0.38,0.628]

10

0

8*

19509168

ITGAM4

0.878[0.614,0.887]

0.534[0.36,0.656]

10

1

8*

11931348

THBS15

0.875[0.53,0.9]

0.532[0.293,0.592]

10

0

8*

17878288

ITGAX

0.873[0.784,0.897]

0.539[0.422,0.691]

10

0

8*

No evidence

CXCR5

0.871[0.755,0.895]

0.537[0.49,0.59]

10

0

8*

17652619

EBI3

0.871[0.801,0.888]

0.529[0.391,0.626]

10

0

8*

19556516

IL64

0.87[0.766,0.893]

0.591[0.361,0.643]

10

0

8*

17465721

TIMP25

0.869[0.645,0.916]

0.584[0.34,0.701]

10

0

8*

10985804


1 Of 10 scores

2 According to table of critical values for W in [6]

3 Pudmed IDs of most recent articles clearly stating that such genes may be drug target candidates

4 Morbid genes according to Morbid Map [46]

5 Genes among those with 10 highest morbidity scores (Table 4)

* Difference statistically significant

Costa et al. BMC Genomics 2010 11(Suppl 5):S9   doi:10.1186/1471-2164-11-S5-S9

Open Data