Classification of genes differentially expressed by human thymic epithelial cells after treatment with CD49e-siRNA versus scramble-siRNA. The figure shows that most of genes up- or down-regulated in cultured human TEC under treatment with CD49e-siRNA (as compared to scramble-siRNA) are not annotated. Yet, among the down-regulated genes with defined functions, 6% code for adhesion molecules. Additionally, a large number of genes related to signal transduction was modulated in CD49e silenced TEC: among those genes whose expression was down-regulated they represented 9%, and corresponded to 23% of the whole amount of up-regulated genes. The classification of 65 down and 66 up-regulated genes in silenced cells to biological functions is given in left and right panels, respectively. The classification into functional categories was defined according to the NCBI, SOURCE (http://smd.stanford.edu/cgi-bin/source/sourceSearch webcite) and DAVID (http://david.abcc.ncifcrf.gov/ webcite) databases.
Linhares-Lacerda et al. BMC Genomics 2010 11(Suppl 5):S2 doi:10.1186/1471-2164-11-S5-S2