Pathome-Genome map. The result of the canonical correlation analysis applied to clinico-pathological findings and gene expression profile. By using this map, the relation between genes and clinical/pathological findings is easily understood. (a) Genes and clinico-pathological findings at the closer position in the map mean that they have higher correlation each other. The enlarged view shows that upregulation of cell cycle-associated genes such as cyclin family CCNA2/B1, MAPK13, BUB, and CDC2, enclosed by blue rectangles, significantly correlated with Portal vein/Hepatic vain invasion, enclosed by green rectangles. This factor is directly associated with well-established clinical criteria such as TNM stage (IVA). (b) Parameter settings, used to draw the map.
Shimokawa et al. BMC Genomics 2010 11(Suppl 4):S19 doi:10.1186/1471-2164-11-S4-S19