Figure 5.

Positioning of WA in the docked structure of h20S. Lactone ring of WA positions itself quite close to the hydroxyl group of Thr1 of h20S receptor thus making itself prone to the nucleophilic attack by Thr1 of β-5 subunit.

Grover et al. BMC Genomics 2010 11(Suppl 4):S15   doi:10.1186/1471-2164-11-S4-S15