Figure 3.

Interactions of the ligand in different docked conformations of b20S. (A) Docked conformation showing proximity of lactone ring’s carbonyl group of WA to the hydroxyl group of N-terminal Thr1 of β-5 subunit of b20S proteasome. (B) Docked conformation showing proximity of three membered epoxy ring of WA to the hydroxyl group of N-terminal Thr1 of β-5 subunit of b20S proteasome.

Grover et al. BMC Genomics 2010 11(Suppl 4):S15   doi:10.1186/1471-2164-11-S4-S15