Table 1

Gene regulations identified in the time-series expression data of yeast cell cycle.

Genes

T

T+1

T+2

T+3


CLB1

    +CLB1(T)→ -CLN2(T+1)

    +CLB1(T) → +SWI5(T+1)

    +CLB1(T+1) → +CDC20(T+3)

    +CLB1(T+2) → +CDC20(T+4)

-CLB1(T) → -CDC20(T+1)

CLB2

+ CLB2(T+1) → +SICl(T+3)

    +CLB2(T+2) → +SWI4(T+5)

    +CLB2(T+3) → +SWI4(T+6)

CLB6

    +CLB6(T)→ -CLB1(T+1)

    +CLB6(T+1) → -CLB1(T+2)

    +CLB6(T+2)→ -CLB1(T+3)

    +CLB6(T) → -CLB2(T+1)

    +CLB6(T+1) → -CLB2(T+2)

    +CLB6(T+2)→ -CLB2(T+3)

CLN1

    -CLN1(T) → -CLB4(T+1)

    -CLN1(T+1) → -CLB4(T+2)

CLN2

    -CLN2(T) → -SWI6(T+1)

    -CLN2(T+2) → +SIC1(T+5)

CLN3

    +CLN3(T) → +SIC1(T+1)

    +CLN3(T) → +CLB6(T+3)

CDC5

    +CDC5(T) → +CDC14(T+1)

    +CDC5(T+1) → +CDC14(T+2)

+CDC5(T+3) → +CDC20(T+5)

    +CDC5(T) → +CDC20(T+1)

    +CDC5(T+1) → +CDC20(T+2)

CDC14

    -CDC14(T) → +CLN1(T+1)

    -CDC14(T+1) → +CLN1(T+2)

    -CDC14(T+2) → +CLN1(T+3)

CDC28

    +CDC28(T) → +SWI4(T+1)

CDC34

-CDC34(T+2) → +CDC34(T+5)

CDC53

+ CDC53(T) → -CLN3(T+1)

CDC55

    +CDC55(T) → +USV1(T+1)

    +CDC55(T+1) → +USV1(T+2)

    +CDC55(T+2) → +USV1(T+3)

+CDC55(T+3) → +USV1(T+5)

    +CDC55(T) → +SWI5(T+1)

    +CDC55(T+1) → +SWI5(T+2)

    +CDC55(T+2) → +SWI5(T+3)

HCM1

    +HCM1(T) → -CLB5(T+1)

+HCM1(T+2) → -CLB5(T+4)

    +HCM1(T) → -CLN1(T+1)

MCM1

+MCM(T+1) → -MBP1(T+2)

+MCM(T+2)→ -MBP1(T+4)

MEC1

    -MEC1(T) → +CBF1(T+1)

-MEC1(T+3) → +CBF1(T+5)

MGA1

    +MGA1(T) → +CDC5(T+1)

PDR3

    +PDR3(T) → +SWI5(T+1)

    +PDR3(T+1) → +SWI5(T+2)

    +PDR3(T+2) → +SWI5(T+3)

SKP1

    -SKP1(T) → -SWI4(T+1)

-SKP1(T+3) → -MBP1(T+4)

SKM1

    -SKM1(T) → +CLB6(T+1)

    -SKM1(T+1) → +CLB6(T+2)

    -SKM1(T+2) → +CLB6(T+3)

    -SKM1(T+3) → +CLB6(T+4)

SIC1

-SIC1(T+1) → +SWI5(T+3)

-SIC 1(T+2) → +SWI5(T+4)

-SIC 1(T+3) → +SWI5(T+5)

-SIC1(T+1) → -CLN2(T+3)

-SIC 1(T+2) → -CLN2(T+4)

-SIC 1(T+3) → -CLN2(T+5)

SWI5

+SWI5(T) → -CLNl(T+1)

+SWI5(T+1) → -CLN1(T+2)

+SWI5(T+3)→ -CLN1(T+4)

    -SWI5(T) → +CLB6(T+1)

SWI6

-SWI6(T+1) → -SKP1(T+2)

-SWI6(T+3) → -CDC20(T+6)

USV1

    +USV1(T)→ -SKM1(T+1)

+USV1(T+1)→ -SKM1(T+3)


Underlined entries denote the regulations determined by experimental methods, and italicized entries denote the regulations implied by previous studies.

Chen et al. BMC Genomics 2010 11(Suppl 4):S14   doi:10.1186/1471-2164-11-S4-S14

Open Data