Table 3

3D-interologs search results using human calcineurin heterodimer as the query

Interactor1

Interactor2

Species

Z score

Rank

P / Na

RSS of BPb

RSS of CCc

Interacting domain1

Interacting domain2


P48456

P48451

Fruit fly

8.98

1

P

0.89

0.85

Metallophos

efand

P23287

P25296

Yeast

8.25

1

P

0.88

1.00

Metallophos

efand

P14747

P25296

Yeast

7.95

2

P

0.88

1.00

Metallophos

efand

Q12705

Q9UU93

Yeast

7.94

1

P

- d

0.78

Metallophos

efand

P48456

P47948

Fruit fly

4.42

16

N

0.41

0.30

Metallophos

efand

P48456

P47949

Fruit fly

4.38

17

N

0.41

0.30

Metallophos

efand

P48456

P49258

Fruit fly

3.99

23

P

0.41

0.56

Metallophos

efand

P48456

Q9VQH2

Fruit fly

3.94

25

N

0.49

0.33

Metallophos

efand

Q8IAM8

P62203

Plasmdium falciparum

3.79

2

P

-

-

Metallophos

efand

P48456

P48593

Fruit fly

3.72

31

P

0.35

0.56

Metallophos

efand

P48456

A1ZAE1

Fruit fly

3.59

34

N

0.00

0.30

Metallophos

efand

Q27889

P48593

Fruit fly

3.42

40

P

-

-

Metallophos

efand

P23287

P06787

Yeast

3.36

5

P

0.61

0.88

Metallophos

efand

P48456

Q9VMT2

Fruit fly

3.03

50

N

0.41

0.30

Metallophos

efand

P48456

Q7K860

Fruit fly

2.99

53

N

0.41

0.30

Metallophos

efand

P14747

P06787

Yeast

2.86

6

P

0.61

0.88

Metallophos

efand

P48454

Q9NP86

Human

2.33

90

N

-

0.00

Metallophos

efand

Q08209

Q9NP86

Human

2.31

91

N

0.41

0.00

Metallophos

efand

P16298

Q9NP86

Human

2.31

91

N

-

0.00

Metallophos

efand


3D-interologs infers 10 positive and 9 negative protein-protein interactions by human calcineurin heterodimer (PDB code 1aui), including calmodulin-dependent calcineurin A subunit alpha isoform (chain A with interacting domain Metallophos) and calcineurin subunit B type 1 (chain B with interacting domain efhand), searching on Integr8 database. a PPI is a positive (P, recorded in IntACT database) or negative case (N, RSS of cellular component is less than 0.4). b,c The relative specificity similarity (RSS) scores, proposed by Wu et al.[43], of Gene Ontology biological process (BP) and cellular component (CC), respectively. d The protein pair is without Gene Ontology annotations in BP or CC.

Lo et al. BMC Genomics 2010 11(Suppl 3):S7   doi:10.1186/1471-2164-11-S3-S7

Open Data