Two frameworks of template-based methods for protein-protein interactions (PPI). (A) For each query protein sequence pair, the method searches 3D-dimer template library to identify homologous templates for exploring the query protein pair, such as MULTIPROSPECTOR . (B) For each structure in 3D-dimer template library, the method searches protein sequence database to identify homologous PPIs of the query structure, such as 3D-interologs.
Lo et al. BMC Genomics 2010 11(Suppl 3):S7 doi:10.1186/1471-2164-11-S3-S7