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This article is part of the supplement: The ISIBM International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (IJCBS)

Open Access Research

Investigation gene and microRNA expression in glioblastoma

Hua Dong12*, Hoicheong Siu1, Li Luo2, Xiangzhong Fang3, Li Jin1 and Momiao Xiong12*

Author Affiliations

1 State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China

2 Human Genetics Center, University of Texas School of Public Health, Houston, TX 77030, USA

3 School of mathematical sciences, Peking University, Beijing, 100871, China

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BMC Genomics 2010, 11(Suppl 3):S16  doi:10.1186/1471-2164-11-S3-S16

Published: 1 December 2010

Additional files

Additional file 1:

A total of 1236 genes were significantly differentially expressed by both T-test and Mann-Whitney Test after Bonferroni correction for multiple tests. The top 10 enriched GO terms and the first 2 significant GO terms clusters were given in sheet 2 and sheet 3, respectively.

Format: XLS Size: 228KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Three sheets gave the list of 131 significant pathways indentified by TAPPA method, the list of 40 significant pathways indentified by Fisher Exact Test and the list of 30 pathways shared by two methods, respectively.

Format: XLS Size: 72KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

A total of 97 microRNAs were significantly differentially expressed by both T-test and Mann-Whitney Test after Bonferroni correction for multiple tests.

Format: XLS Size: 33KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

The 1,094 matched miRNA-gene pairs including 70 microRNAs and 661 genes predicted by both our results and miRanda algorithm.

Format: XLS Size: 127KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

A total of 83 pathways targeted by 94 microRNAs were listed after Bonferroni correction for multiple tests.

Format: XLS Size: 198KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional files 6:

We have attached the Matlab code for T-Test, Mann-Whitney Test and linear regression in additional files 6

Format: TXT Size: 5KB Download file

Open Data