Table 2

Grouping of imidase related proteins1

Group

Member number

Sequence identity

Imidase Activity


I. Imidase (target enzyme)

5

98-100%

Yes

II. Sequence related proteins2

43

50-80%

No

III. Functionally identical enzymes3

16

30-40%

Yes

IV. Functionally related enzymes4

63

25-48%

Yes

V. Putative proteins5

29

30-60%

Unknown


1Proteins are grouped according to properties related to the target enzyme (rat imidase)

2Sequence-related proteins, referred to as dihydropyrimidinase related proteins (DRPs), with no imidase activity.

3Functionally identical enzymes, referred to as bacterial imide-hydrolyzing enzyme or hydantoinase, in which substrate spectrums were virtually identical to that of the target enzyme.

4Functionally-related enzymes, including dihydroorotase, allantoinase, and urease. Each enzyme catalyzes its own distinct substrate that contains an imide functional group.

5 Putative proteins are referred to as gene products with unknown function.

Hung et al. BMC Genomics 2010 11(Suppl 3):S14   doi:10.1186/1471-2164-11-S3-S14

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