Histograms of Gene Expression Profiles(a) Histogram of the expression fold change of 209 verified targets in different miRNAs transfection experiments. Notice that a portion of the true targets were not down-regulated. (b) Histogram of genome-wide expression of hsa-miR-124 transfection The genome-wide expression profile consists of those for both positive targets and negative targets. Since positive targets for a small portion of the genome, the distribution of genome expression looks like the distribution of the negative targets.
Liu et al. BMC Genomics 2010 11(Suppl 3):S12 doi:10.1186/1471-2164-11-S3-S12