Table 1

Experimentally determined tyrosine-phosphorylated effectors and their motifs

Effector

Pathogen

Locus of protein

Motif (phosphorylated Y position)


CagA

H.Ppylori

NP_207343

EPIYAKVNK

Y-899

EPIYTQVAK

Y-918

EPIYATIDD

Y-972


Ankyrin

Anaplasma phagocytophilum

ABB84853

ESIYEEIKD

Y-940

ESIYEEIKD

Y-967

ESIYEEIKD

Y-994

EDLYATVGA

Y-1028

ESIYADPFD

Y-1056

ESIYADPFA

Y-1074

EPIYATVKK

Y-1098


BepD

Bartonella henselae

YP_034066

EPLYAQVNK

Y-32

NPLYEGVGG

Y-114

NPLYEGVGS

Y-176

EPLYAQVNK

Y-211

NPLYEGVGG

Y-293

NPLYEGVGP

Y-355


BepE

Bartonella henselae

YP_034067

EPLYATVNK

Y-37

ETIYTTVSS

Y-91


BepF

Bartonella henselae

YP_034068

TPLYATPSP

Y-149

EPLYATPLP

Y-213

EPLYATPLP

Y-241

EPLYATAAP

Y-297

EPLYATPLP

Y-269


Tir

Escherichia Eoli

AAC38390

EHIYDEVAA

Y-474


Tir

Citrobacter rodentium

AAL06376

EPIYDEVAP

Y-468


Trap

Chlamydie trachomatis

YP_001654788

ENIYENIYE

Y-136

ENIYENIYE

Y-238

ENIYENIYE

Y-390


CagA: cytotoxin associated gene A [7,8,10,52-56]; BepD: Bartonella henselae protein D [14-16,57]; BepE: Bartonella henselae protein E [14-16,57]; BepF: Bartonella henselae protein F [14-16,57]; Tir: translocated intimin receptor [58-60] ; Trap: Translocated actin-recruiting protein [61-63] . The first five amino acids of the listed sequences in the table correspond to the EPIYA motif.

Xu et al. BMC Genomics 2010 11(Suppl 3):S1   doi:10.1186/1471-2164-11-S3-S1

Open Data