HNF4A is a common hub for networks derived from alignment data and TargetScan predictions. Gene interaction network on the left (A) is derived from the dataset of genes with overlapping regions corresponding to peaks from previous mapping. The other gene interaction networks (B) is derived from computationally predicted gene targets from TargetScan. Comparing both gene interaction network, similar topology was observed with HNF4A as a node amongst the interactions suggesting HNF4A as a possible downstream target for let-7 family miRNAs.
Koh et al. BMC Genomics 2010 11(Suppl 1):S6 doi:10.1186/1471-2164-11-S1-S6