Table 3

Key milestones of computational protein complex detection


Main contributions

MCODE [27]

MCODE pioneered the computational detection of protein complexes from PPI networks.

MCL [30,31]

MCL is a widely used method [33-36] with good convergence and robustness [32]

Krogan et al. [33]

They provided and exploited a comprehensive TAP dataset for computational protein complex detection.

Gavin et al. [3]

In addition to providing a TAP dataset widely used for protein complex detection, they described the inherent organization of protein complexes with core-attachment structures.

Sharan et al. [78-80]

They systematically conducted cross-species analysis of PPI networks to derive evolutionary information for protein complex detection.

Li et al. BMC Genomics 2010 11(Suppl 1):S3   doi:10.1186/1471-2164-11-S1-S3

Open Data