This article is part of the supplement: International Workshop on Computational Systems Biology: Approaches to Analysis of Genome Complexity and Regulatory Gene Networks

Open Access Research

Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases

Pavel A Karpov1, Elena S Nadezhdina23, Alla I Yemets1, Vadym G Matusov1, Alexey Yu Nyporko1, Nadezhda Yu Shashina3 and Yaroslav B Blume1*

Author Affiliations

1 Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, 04123 Kyiv, Ukraine

2 Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russian Federation

3 AN Belozersky Institute of Physical-Chemical Biology, Moscow State University, Leninsky Gory, 119992 Moscow, Russian Federation

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BMC Genomics 2010, 11(Suppl 1):S14  doi:10.1186/1471-2164-11-S1-S14

Published: 10 February 2010


A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.