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Open Access Research article

An integrated functional genomic study of acute phenobarbital exposure in the rat

Claire L Waterman1, Richard A Currie23, Lisa A Cottrell23, Jacky Dow23, Jayne Wright23, Catherine J Waterfield23 and Julian L Griffin1*

Author Affiliations

1 Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK

2 Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK

3 Current address: Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK

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BMC Genomics 2010, 11:9  doi:10.1186/1471-2164-11-9

Published: 6 January 2010

Additional files

Additional file 1:

Metabolite changes in response to increasing dose of phenobarbital. Metabolite changes in liver and plasma in response to increasing dose of PB as detected by 1H-NMR spectroscopy and GC-MS across the time course of the study.

Format: DOCX Size: 16KB Download file

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Additional file 2:

Pathways identified as perturbed by transcriptomic analysis. Pathways and biological processes which are over represented in the set of genes whose expression is altered by phenobarbital. Genes are grouped by temporal expression profile as described Figure 4.

Format: DOCX Size: 14KB Download file

Open Data

Additional file 3:

Remodelling of the lipid profile of liver tissue following PB treatment. Changes in intact phospholipids in response to increasing dose of PB as detected by negative mode direct infusion ESI-MS of extracts from liver tissue.

Format: DOC Size: 1.8MB Download file

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Additional file 4:

Study design for animal experiment. This table depicts the animal numbers used in the design of the study.

Format: XLS Size: 24KB Download file

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Additional file 5:

Metabolomics Standards Initiative Compliant Metadata. The excel spread sheets contain all the metabolomics data collected by NMR spectroscopy and GC-MS of fatty acid methyl esters according to the Standard reporting requirements for biological samples in metabolomics experiments: mammalian/in vivo experiments.

Format: XLS Size: 1.3MB Download file

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Open Data