Distribution of telomere-proximal breaks in sheared genomic DNA from Neurospora crassa. Trace archive data from the N. crassa genome sequencing project were retrieved from NCBI. BLAST searches were used to identify raw sequence reads derived from telomere-proximal regions. The positions of DNA breaks were determined by mapping the starts of the reads onto telomeric contigs that had been fully assembled through targeted finishing efforts. Shown are the results of a sliding window analysis of break distribution near to six telomeres. Window size was 500 bp and step size was 100 bp. Black line = break distribution in the circular molecular; red line = distribution in the linear molecule. The scale at the bottom represents the distance from the nearest edge of the window to the telomere.
Schwartz and Farman BMC Genomics 2010 11:87 doi:10.1186/1471-2164-11-87