Distribution of DNA breaks in the regions flanking the SwaI cut site. The positions of breaks were determined by mapping the starts of sequence reads back to the cosmid assembly. Only reads that started with a visible pBC polylinker sequence were included. Shown are the results of a sliding window analysis of break distribution in the circular and linear DNA samples sheared to an average size of 3.8 kb. Window size was 1 kb and step size was 100 bp. The scale at the bottom represents the distance from the nearest window edge to the SwaI site.
Schwartz and Farman BMC Genomics 2010 11:87 doi:10.1186/1471-2164-11-87