Power, false positive rates, and false discovery rates for a) iHS and b) ALnLHu. To obtain critical values, we combined loci from neutral simulations with loci from selection simulations in proportion to the fraction of the genome influenced by positive selection . Our implementation of each test followed the methodology employed in the empirical genome scans from  (iHS) and Wang et al., 2006 (ALnLH). The false discovery rate was between 0 and 0.53 for iHS, and between 0.74 and 0.96 for ALnLHu. To approximate the histories of the populations in the original studies, we combined results from simulations of African and European populations based on the best fitting model in . The locus recombination rate for each simulation was set to an exponential random variate with mean equal to 1 cm/Mb. For other simulation parameters, see Figure 2.
Huff et al. BMC Genomics 2010 11:8 doi:10.1186/1471-2164-11-8