Resolution:
## Figure 1.
Power to detect selection from single-site statistics with a constant recombination
rate. For all figures, the power was averaged across 4 population histories of constant
size, expansion, expansion with migration, and bottleneck with migration. Both ALnLH_{p }and iHS performed quite well in most models. The power of LRH was consistently lower
than the other statistics. Neutral simulations for each set of simulation parameters
provided the critical values for each statistic. a. Power to detect selection for allele frequencies between 0.2 and 0.8 with a simulated
region of 1 Mb at a significance level of 0.01. ALnLH_{p }and ALnLH_{u }were equivalent when allele frequencies were close to 0.5, but the power of ALnLH_{u }drops by 40% with allele frequencies of 0.2 and 0.8. b. Power to detect selection in simulated regions of 0.1 Mb to 1 Mb. The power was calculated
from an equal proportion of allele frequencies 0.2, 0.4, 0.6, and 0.8 for the favored
allele at a significance level of 0.01. The average power increased substantially
for ALnLH and iHS out to nucleotide lengths of 400 Kb, beyond which there was little
improvement. c. Power to detect selection for significance levels of 0.005 to 0.05 with simulated
region of 1 Mb and an equal proportion of allele frequencies 0.2, 0.4, 0.6, and 0.8
for the favored allele. The average power of ALnLH_{p }and iHS was over 0.9 for significance levels of 0.01 or greater.
Huff |