Figure 1.

Power to detect selection from single-site statistics with a constant recombination rate. For all figures, the power was averaged across 4 population histories of constant size, expansion, expansion with migration, and bottleneck with migration. Both ALnLHp and iHS performed quite well in most models. The power of LRH was consistently lower than the other statistics. Neutral simulations for each set of simulation parameters provided the critical values for each statistic. a. Power to detect selection for allele frequencies between 0.2 and 0.8 with a simulated region of 1 Mb at a significance level of 0.01. ALnLHp and ALnLHu were equivalent when allele frequencies were close to 0.5, but the power of ALnLHu drops by 40% with allele frequencies of 0.2 and 0.8. b. Power to detect selection in simulated regions of 0.1 Mb to 1 Mb. The power was calculated from an equal proportion of allele frequencies 0.2, 0.4, 0.6, and 0.8 for the favored allele at a significance level of 0.01. The average power increased substantially for ALnLH and iHS out to nucleotide lengths of 400 Kb, beyond which there was little improvement. c. Power to detect selection for significance levels of 0.005 to 0.05 with simulated region of 1 Mb and an equal proportion of allele frequencies 0.2, 0.4, 0.6, and 0.8 for the favored allele. The average power of ALnLHp and iHS was over 0.9 for significance levels of 0.01 or greater.

Huff et al. BMC Genomics 2010 11:8   doi:10.1186/1471-2164-11-8
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