An example of amino acid properties change of CEN. PK113-7D compared to S288c: the gene ERG8 of the ergosterol synthesis pathway. The gene ERG8 of the ergosterol synthesis pathway contains a total of 4 nonsynonymous SNPs, two of which, located at nucleotide positions 192 and 75, are analyzed here. The top plots show the CEN.PK Match Frequency, Dominanat AA Frequency, S288c Match Frequency, and Conversation Distance. The middle plots show the frequency (fraction) of each categorization across the amino acid sequences resulting from Pfam multi-sequence alignment. The bottom plots shows the characterization of the original S288c amino acid (symbol: blue bar) and the CEN.PK113-7D amino acid (symbol: red bar). The gene ERG8 contained a total of 4 nonsynonymous SNPs, and Additional file 1, Figure S5 includes the other 2 nonsynonymous SNPs (nucleotide positions 49 and 247).
Otero et al. BMC Genomics 2010 11:723 doi:10.1186/1471-2164-11-723