Additional file 3.

Gene Ontology analysis of the predicted targets of selected sub-clusters of miRNAs with comparable expression profiles. Schematic representation of selected GO/KEGG categories relevant to eye development and function that were enriched among the targets of at least 70% of the miRNAs present within each sub-cluster. The miRNAs within each sub-cluster considered for functional analysis of their predicted targets are listed on the last column of the table. The tissues in which each cluster was predominantly expressed are listed in the column labeled "Expression". For each GO/KEGG category the percentage of representation of this term among the miRNAs analyzed is reported within the cell. The terms of BP Biological Processes and KEGG pathways that relate to similar cellular functions are arbitrarily coloured for readers' clarity. The exact reference numbers that correspond to the GO Biological Processes and KEGG pathways of the table are the following: cell adhesion (GO:0007155); axonogenesis (GO:0007409); morphogenesis of a branching structure (GO:0001763); modification-dependent macromolecule catabolic process (GO:0043632); epithelium development (GO:0060429); transmission of nerve impulse (GO:0019226); cell migration (GO:0016477); cell motion (GO:0006928); neuron development (GO:0048666); neuron differentiation (GO:0030182); neuron projection development (GO:0031175); pattern specification process (GO:0007389); cell-cell signaling (GO:0007267); synaptic transmission (GO:0007268); vesicle-mediated transport (GO:0016192); vasculature development (GO:0001944); Wnt signaling pathway (GO:0016055); regulation of actin cytoskeleton (KEGG: mmu04810); Adherens junction (KEGG: mmu04520); Axon guidance (KEGG: mmu04360); Focal adhesion (KEGG: mmu04510); Glioma (KEGG: mmu05214); GnRH signaling pathway (KEGG: mmu04912); Melanogenesis (KEGG: mmu04916); Melanoma (KEGG: mmu05218); Neurotrophin signaling pathway (KEGG: mmu04722); Wnt signaling pathway (KEGG: mmu04310); MAPK signaling pathway (KEGG: mmu04010); TGF-beta signaling pathway (KEGG: mmu04350). Abbreviations are, cor: cornea; ret: retina; RPE: retinal pigment epithelium.

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Karali et al. BMC Genomics 2010 11:715   doi:10.1186/1471-2164-11-715