Table 2

Summary of major QTLs detected in the F2 mice.

Chr

Best location,

cM (CI)

Closest marker

to peak LOD

Peak LOD

GW Sig.

%

Phenotype value


B6/B6 (n)

B6/TH (n)

TH/TH (n)


Triglyceride (mg/dl)

8 wk

1

95.7

(25.7, 96.9)

D1Mit113

3.67

S

3.63

157 ± 7 (89)a

164 ± 4 (201)a

188 ± 6 (78)b

12 wk

11

65

(20, 79)

D11Mit132

3.76

S

1.72

153 ± 5 (90)a

169 ± 4 (182)b

173 ± 6 (109)b

20 wk

4

31.3

(21.3, 41.3)

D4Mit178

4.47

VS

4.82

161 ± 6 (92)a

178 ± 5 (201)a

210 ± 9 (83)b

24 wk

8

55.75

(50, 55.7)

D8Mit242

3.94

S

4.29

159 ± 7 (97)a

185 ± 5 (186)b

199 ± 8 (91)b


Cholesterol (mmol/l)

8 wk

1

86.7

(84.7, 87.7)

D1Mit113

11.83

VS

4.96

2.5 ± 0.1 (88)a

2.9 ± 0.1 (200)b

3.2 ± 0.1 (77)c

12 wk

1

89.7

(86.7, 96.7)

D1Mit113

6.55

VS

6.76

2.6 ± 0.1 (88)a

3.2 ± 0.1 (211)b

3.5 ± 0.1 (79)c

3

10.6

(5.6, 11.6)

D3Mit304

4.07

S

4.31

3.5 ± 0.1 (102)a

3.0 ± 0.1 (177)b

2.9 ± 0.1 (99)b

16 wk

1

93.7

(86.7, 96.9)

D1Mit113

7.99

VS

8.62

2.6 ± 0.1 (92)a

3.0 ± 0.1 (212)b

3.5 ± 0.1 (80)c

20 wk

1

92.7

(86.7, 96.9)

D1Mit113

9.83

VS

11.05

2.8 ± 0.1 (89)a

3.2 ± 0.1 (209)b

3.9 ± 0.1 (79)c


Glucose (mg/dl)

24 wk

4

67.3

(66.3, 70.3)

D4Mit312

6.13

VS

2.89

147 ± 4 (102)a

167 ± 4 (205)b

172 ± 8 (66)b


Body weight (g)

20 wk

11

41

(32, 43)

D11Mit41

4.51

VS

2.17

36 ± 0.5 (72)a

38 ± 0.4 (199)b

38 ± 0.5 (103)b

24 wk

11

41

(32, 43)

D11Mit41

4.43

VS

1.74

38 ± 0.6 (72)a

40 ± 0.4 (197)b

40 ± 0.6 (103)b

1

35.7

(33.7, 44.7)

D1Mit215

3.52

S

4.15

37 ± 0.6 (92)a

40 ± 0.4 (180)b

41 ± 0.6 (101)b


Fat pad weight (g)

IG

1

41.7

(33.7, 44.7)

D1Mit215

5.38

VS

5.88

0.79 ± 0.05 (92)a

1.02 ± 0.04 (179)b

1.12 ± 0.05 (101)b

ED

1

39

(33.7, 44.7)

D1Mit215

6.20

VS

7.02

1.15 ± 0.06 (92)a

1.43 ± 0.05 (179)b

1.61 ± 0.06 (101)c

MS

1

41.7

(33.7, 44.7)

D1Mit215

4.14

S

4.78

0.32 ± 0.02 (92)a

0.42 ± 0.02 (179)b

0.43 ± 0.02 (101)b

RP

1

39

(33.7, 44.7)

D1Mit215

4.62

VS

5.40

0.33 ± 0.02 (91)a

0.44 ± 0.02 (179)b

0.47 ± 0.02 (101)b

SC

1

39

(33.7, 44.7)

D1Mit215

6.39

VS

7.24

0.37 ± 0.03 (92)a

0.54 ± 0.03 (179)b

0.56 ± 0.03 (101)b

Sum

1

40.7

(33.7, 44.7)

D1Mit215

6.26

VS

7.01

2.9 ± 0.16 (92)a

3.8 ± 0.13 (179)b

4.2 ± 0.18 (101)b


Carcass weight (g)

11

40

(32, 43)

D11Mit41

4.48

VS

1.88

32 ± 0.4 (72)a

34 ± 0.3 (197)b

34 ± 0.4 (102)b

14

72.5

(65.5, 76.1)

D14Mit107

3.67

S

4.53

34 ± 0.5 (81)a

34 ± 0.3 (193)a

32 ± 0.4 (96)b


Phenotypic data are presented as mean ± sem. Means labeled with different letters are significantly different from one another (P < 0.05). Chr, chromosome; CI, 2 LOD support interval; %, total variance explained by R-square; IG, inguinal; ED, epididymal; MS, mesenteric; RP, retroperitoneal including perirenal; SC, subscapular; Sum, sum of the 5 fat pads above; GW Sig., genome-wide significance; S, significant; VS, very significant.

Stewart et al. BMC Genomics 2010 11:713   doi:10.1186/1471-2164-11-713

Open Data