Table 2

Evaluation of asMIPs using splicing controls and qPCR data

Statistic

R-Array

R-Seq

M-Array

M-Seq


AUC-controls1

0.90

0.96

0.89

0.96

AUC-qPCR2

0.65

0.65

0.65

0.76

CorrqPCR-controls3 (ρ)

0.84

0.86

0.63

0.82

CorrqPCR-total2 (ρ)

0.44

0.64

0.29

0.59


The table includes results from both the R- and M-score analyses (R- and M-), as well as data from asMIPs quantified with either arrays (Array) or sequencing (Seq). AUC and Pearson correlation (Corr, ρ) values are reported.

1 asMIP data was compared to tissue specific, splicing controls from the literature: 58 tissue specific, alternatively spliced junctions [10,20] and 99 predicted constitutive junctions [21,34].

2 asMIP data was compared to the complete set of qPCR data, 235 tissue specific splice events were analyzed.

3 asMIP data from the set of splicing controls was compared to qPCR data from the same set of controls [10,20,21,34], 34 tissue specific splice events were analyzed.

Lin et al. BMC Genomics 2010 11:712   doi:10.1186/1471-2164-11-712

Open Data