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Open Access Research article

Knobbed acrosome defect is associated with a region containing the genes STK17b and HECW2 on porcine chromosome 15

Anu Sironen1*, Pekka Uimari1, Szabolcs Nagy2, Sándor Paku3, Magnus Andersson4 and Johanna Vilkki1

Author Affiliations

1 Agrifood Research Finland, MTT, Biotechnology and Food Research, Genomics, FI-36100 Jokioinen, Finland

2 University of Pannonia, Institute of Environmental Sciences, H-8200 Veszprem, Hungary

3 First Department of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Hungary

4 University of Helsinki, Department of Clinical Veterinary Sciences, Helsinki, Finland

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BMC Genomics 2010, 11:699  doi:10.1186/1471-2164-11-699

Published: 9 December 2010

Additional files

Additional file 1:

The KAD associated region in the Finnish Yorkshire pig localized on porcine chromosome 15. The KAD associated homozygous region in the Finnish Yorkshire was identified in chromosome 15 between base pairs 93723216 and 94155055. A promising candidate gene Ubiquitin-protein ligase E3 (HECW2) is located within this region at the same position as two markers with lowest P-values (highlighted by circles). Another gene STK17b was also located within the homozygous region; however the known function of this gene in apoptosis would not infer a role for STK17b in KAD.

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