Repeat heterozygosity, point mutation heterozygosity and raw counts for homopolymers (A, C, E) and dimers (B, D, F). Black lines and squares correspond to A/T homopolymers, red lines and squares correspond to C/G homopolymers. Colors corresponding to the dimers are green:AC/CA/GT/TG, blue:AG/GA/CT/TC, grey:AT/TA, magenta:CG/GC. (A) Percent repeat heterozygosity for homopolymers A/T (r2= 0.925, p < 1e-11) and C/G (r2= 0.899, p < 1e-10) with increases in heterozygosity highest between 7-11 repeats. C/G heterozygosity is approximately 3-fold higher than A/T heterozygosity. (B) Percent repeat heterozygosity for dimers with AC> AG> AT > CG (r2 = 0.862, p < 1e-5; r2 = 0.891, p < 1e-5; r2 = 0.736, p < .01; r2 = 0.539, p < .2). (C) Point mutation per nucleotide for homopolymers C/G (r2 = 0.905, p < 1e-12) and A/T (r2 = 0.446, p < .01), highest increase in polymorphism occurring at 7-11 repeats. (D) Percent point mutation/per base heterozygosity of microsatellites, AT/CG loci with higher proportions of point mutations than AC/AG types. (E) Raw genome counts of A/T and C/G homopolymers with frequency changes between 7-11 repeats. (F) Raw counts of dimers AC/AG/AT/CG.
Sung et al. BMC Genomics 2010 11:691 doi:10.1186/1471-2164-11-691