Results of microarray analysis in myo1Δ strains. A) Venn diagram illustrating the relative percentage of regulated genes. Results of global expression of mRNAs were extracted from Rodríguez-Quiñones et al. . Ribosome-associated mRNAs regulated by translation were identified in the current study. Co-regulated genes are defined as differentially expressed mRNAs that were regulated in both the global analysis and ribosome-associated RNA studies. The percentage shown for each category of genes reflects the number of represented genes relative to the total number of regulated genes (1644). B) Gene Set Enrichment Analysis (GSEA) for Biological Process categories. Differentially regulated mRNAs were grouped according to Biological Process and represented graphically relative to the total population of genes in the yeast oligonucleotide microarray. Shown are histograms representing the distribution of individual genes by Density versus t-value. Only those Biological Process categories that reflected a statistically significant change in their average t-value are shown. The p-value cutoff was p≤ 0.00056. Red lines represent the distribution of genes in each specific Biological Process category. Black lines represent the distribution of all genes in the microarray. See Methods section for details.
Rivera-Ruiz et al. BMC Genomics 2010 11:690 doi:10.1186/1471-2164-11-690