Model of TR4-ELK4 cis module. Gene promoters bound by both transcription factors, TR4 and ELK4, lack the DR1 element, but contain an ETS motif. This suggests that TR4 binding at these sites is facilitated through an ETS family member such as ELK4, possibly with the help of a bridging protein. TR4 may then augment ELK4 binding through non-specific DNA association, as depicted, or by serving as a non-DNA binding scaffold for additional accessory proteins.
O'Geen et al. BMC Genomics 2010 11:689 doi:10.1186/1471-2164-11-689